FORMULATION OF MUCOAHESIVE GASTRORETENTIVE TABLET OF DILTIAZEM HYDROCHLORIDE

FORMULATION OF MUCOAHESIVE GASTRORETENTIVE TABLET OF DILTIAZEM HYDROCHLORIDE

AngličtinaMěkká vazbaTisk na objednávku
Shinde, Anilkumar
LAP Lambert Academic Publishing
EAN: 9786200431820
Tisk na objednávku
Předpokládané dodání v pondělí, 10. února 2025
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Běžná cena: 1 291 Kč
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Podrobné informace

The objective of present study was to formulate an oral mcoadhesive tablet of diltiazem hydrochloride.Investigate the effect of amount of HPMC K4M and sodium alginate on the sustained release and gastric residence time of dosage form. The mucoadhesive tablet prepared by direct compression method was used varying concentrations of HPMC K4M and Sodium alginate and (1:1, 1:1.5, 1:2) Drug and Polymer ratio.The formulations were evaluated and results revealed that FTIR studies showed no evidence of interactions between drug and excipients used. The mucoadhesive strength, residence time and drug content of formulation F3 was found to be 26.35 ± 1.15 mg, >7.5hrs, and 98.75 ± 0.05 % respectively. The formulation F3 exhibited sustained drug release i.e. 75.71% in 12 h. The in vitro release kinetics studies reveal that formulations fit well with zero order kinetics and mechanism of drug release is Super case II transport. The study was concluded that formulation of mucoadhesive tablets from the cumulative % drug release study reveals that increase in the concentration of adhesive polymers cause slow the drug release. Tablet of DTZ can be beneficial in treatment of hypertension.
EAN 9786200431820
ISBN 6200431825
Typ produktu Měkká vazba
Vydavatel LAP Lambert Academic Publishing
Stránky 56
Jazyk English
Rozměry 220 x 150
Autoři More, Harinath; Shinde, Anilkumar