Growth Factors In Periodontal Regeneration : Promising Helpers

Periodontitis can be defined as an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or a group of specific microorganisms, resulting in progressive destruction of periodontal ligament and alveolar bone with pocket formation, recession or both. The ultimate goal of periodontal therapy has been to regenerate the lost periodontal tissues for optimal function and esthetics. To attain this goal, researchers all over the world have been conducting clinical trials in different modalities of periodontal therapy. Current therapeutic modalities for periodontal regeneration include the use of bone grafts, guided tissue regeneration using barrier membranes, Cdf, root surface biomodification etc. Among these guided tissue regeneration has been the most promising, it provides a space for migration of the periodontal ligament cells and prevents the formation of a long junctional epithelium. But what is lacking in this procedure is the induction and differentiation of cells responsible for periodontal regeneration. So, to overcome this Growth factors have been used to promote regeneration of supporting tissue after periodontal disease