Some biochemical indices in the development of acute pancreatitis

The paper covers the issues of acute experimental pancreatitis not only from the position of structural and functional shifts in the pancreas, but also taking into account changes in other parenchymatous organs - liver and kidneys, actively involved in homeostasis. Depression of practically all liver functions, especially detoxification, manifested by decreased activity of monooxygenase system enzymes; impaired excretory function of kidneys was found. Lifelong study of microhemocirculatory channel of liver, kidneys and pancreas, quantitative assessment of local blood flow parameters allowed to reveal a close relationship between the degree of damage of pancreas tissue and the severity of microcirculatory shifts of the studied organs. The influence of acute pancreatitis on rheological properties of blood is shown: changes in phospholipid and fatty acid spectrum of membranes of blood forming elements, increase of their peroxidation, revealed on the example of erythrocytes. It is intended for physiologists, pathophysiologists, biochemists, senior students of medical institutes and clinicians interested in the pathogenetic aspects of pancreatitis.