Structural and Evolutionary Genomics

Structural and Evolutionary Genomics

EnglishEbook
Bernardi, Giorgio
Elsevier Science
EAN: 9780080461878
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Detailed information

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a &quote;regional&quote; control is exerted by natural selection (essentially negative or purifying selection). A &quote;neo-selectionist&quote; model is proposed for genome evolution.* Summarizes the existing knowledge on genome organization and evolution in a self-containedbook* Discusses important open problem, without refraining from criticism wheneverappropriate
EAN 9780080461878
ISBN 0080461875
Binding Ebook
Publisher Elsevier Science
Publication date December 19, 2005
Language English
Country Uruguay
Authors Bernardi, Giorgio
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