Transcription Factors in Cellular Response to Oxidative Stress

Transcription Factors in Cellular Response to Oxidative Stress

EnglishPaperback / softback
Oluwafemi, Funmilola Adebisi
LAP Lambert Academic Publishing
EAN: 9786200093035
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Organisms are constantly exposed to many different forms of reactive oxygen species (ROS) and reactive nitrogen species (RNS) from both endogenous and exogenous means that damage proteins, nucleic acids, and lipids, leading to loss of biological function implicated in degenerative diseases. Organisms possess a battery of antioxidant systems (enzymes, vitamins, metabolites) as a defense against ROS-mediated oxidative damage that can prevent the formation of these ROS/RNS or convert them to inactive derivatives. These antioxidants are naturally produced in situ, or supplied through foods and/or supplements. An imbalance between oxidants and antioxidants favoring oxidants, potentially leading to damage, is called oxidative stress. Some pathways are activated in response to oxidative stress and are preferentially linked to enhanced survival or associated with cell death as therapeutic interventions. These pathways exert in uence through modulation of transcription factors activities effecting changes in gene expression pattern, especially antioxidant-related genes. Discussed are transcription factors, activation mechanisms of signaling pathways and roles in specific diseased condition.
EAN 9786200093035
ISBN 6200093032
Binding Paperback / softback
Publisher LAP Lambert Academic Publishing
Pages 104
Language English
Dimensions 220 x 150
Authors Oluwafemi, Funmilola Adebisi