Novel Pyrazoline Derivatives and their Possible Biological Activities

The eco-friendly solvent-free approach using microwave irradiation opens numerous possibilities for conducting rapid heterocyclic synthesis, via cycloaddition and cyclocondensation reactions, using a variety of supported reagents on mineral oxides and phase transfer catalysis conditions. The absence of solvent reduces considerably the reaction time and generally improves the yields. Due to the wide range of applications of microwaves, this method of synthesis has been selected. Pyrazolines are also known to possess antioxidant property wherein they scavenge free radicals which are one of the causes for cell damage leading to several diseases. It was our interest to synthesize the pyrazoline derivatives and evaluate them for their antioxidant activity.