Protein Folding Protocols

Protein Folding Protocols

EnglishHardback
Humana Press Inc.
EAN: 9781588296221
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Detailed information

Protein Folding Protocols presents protocols for studying and characterizing steps and conformational ensembles populating pathways in protein folding from the unfolded to the folded state. It further presents a sample of approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. Protein folding is a crucial step in the transfer of genetic information from the DNA to the protein. The Genome Project has led to a huge number of available DNA sequences and, therefore, protein sequences. The Structural Genomics initiative largely aims to obtain “new” folds not currently present in the Protein Data Bank. Yet, the number of available structures inevitably lags behind the number of sequences. At the same time, an equally important problem is to find out the types and scope of dissimilar (nonhomologous) protein sequences that adopt a similar fold. Assembling data and comprehension of the sequence space of protein folds should be very useful in computational protein structure prediction. This would enhance the scope of homology modeling, which currently is the method of choice. Thus, experimental and theoretical studies on the relationship between sequence and structure are critical. Figuring out the relationship between sequence and structure would further assist in the prediction of fibril structures observed in protein misfolding diseases, and in figuring out the conformational changes and dynamics resulting from mutations. Protein folding is one of the most important and challenging problems in current molecular and chemical biology.
EAN 9781588296221
ISBN 1588296229
Binding Hardback
Publisher Humana Press Inc.
Publication date July 24, 2006
Pages 328
Language English
Dimensions 235 x 155
Country United States
Readership Professional & Scholarly
Illustrations XIV, 328 p. 111 illus.
Editors Bai Yawen
Series Methods in Molecular Biology