The metabolic study of western style diet on uninephrectomized rats

A chronic nutrient overload causes various tissue-specific and systemic metabolic dysfunctions that increase the risk of kidney damage and promote CKD. Especially, the combination of high amounts of saturated fat, fructose and salt promotes dyslipidemia, hormonal disturbances, oxidative stress, inflammation, fibrosis with impaired glomerular function hypertension reduced nephron number and susceptibility to obesity-related renal damage have suggested that obesity is associated with higher glomerular hyperfiltration, higher risks of proteinuria and CKD . WSD lead to increase fatty acids that inhibit IRS (insulin resistance). Insulin resistance stimulates lipogenesis and this increased by fructose. Renal damage due to obesity is severe in conjunction with uninephrectomy.